ABSTRACT
Objective To investigate the change of AQP1 and AQP2 before and after the release of obstruction and explore the relationship between reabsorption dysfunction of renal tubule and the change of AQPs. Methods The model of unilateral ureter obstruction (UUO) was established by surgery. Western blot and immunohistochemistry were used to study the expression of AQPs before and after obstruction. Results In UUO model, both AQPs began to down-regulate one day after obstruction, the expression of both AQPs became lower one day after the release of obstruction. And they started to up-regulate 7 day after the release of obstruction. AQP2 became normal since 14 days after the release of obstruction, and AQP1 became normal since 21 days after the release of obstruction. Conclusion The expression of AQP1 and AQP2 were descended in hydronephrosis. The dysfunction of renal tubule and the osmotic-dependent polyuria after the release of obstruction in UUO were caused by the down - regulation of AQPs.
ABSTRACT
Objective To investigate the effective methods for treatment of severe chest trauma with multiple organ injury. Methods The injury conditions and the early treatment measures in 87 cases of severe chest trauma with multiple organ injury (especially within 48 h after injury) were analyzed retrospectively. Results Of the 78 patients, 61 patients survived, and 26 died (including 2 patients who abandoned treatment). The total mortality was 29 89%. Primary operation was performed on 37 patients with multiple organ injury, but 7 died (18 92%). Conclusion Diagnosis while rescuing, effective countershock treatment, early operation, protection of visceral functions, and preventive mechanical ventilation may be the important measures to guarantee the success of treatment of severe chest trauma with multiple organ injury.
ABSTRACT
Objective To evaluate urethroplasty using circular fasciocutaneous prepuce flap for the treatment of extensive urethral stricture. Methods From 1993 to 1998,one stage urethroplasty using distal prepuce circular fasciocutaneous flap with Buck's fascia was conducted for 7 cases of extensive anterior urethral stricture of 6～10 cm long. Results All the patients have been followed up for 14～58 months with good voiding.No postoperative urethral stricture has been observed. Conclusions One stage urethroplasty using circular fasciocutaneous prepuce flap is an ideal operative procedure for the treatment of extensive anterior urethral stricture.The technique is simple and convenient to carry out.